Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Erlangen-Nürnberg Medical School
• Treatments: Spironolactone

Criteria

Inclusion Criteria:

• Clinical diagnosis hypertension (BP higher than 139/89)

Exclusion Criteria:

• Antihypertensive pretreatment

• Contraindications against spironolactone

• Being unable to understand or comply with study procedures