Implantation Enhancement by Elective Cryopreservation of All Viable Embryos

• Status: Completed
• Trial end date: 2017-02-28
• Target enrollment: 0
• Participant gender: Female

Summary

A randomised controlled open-label clinical trial to compare the clinical pregnancy rates between fresh embryo transfer and elective all-embryo vitrification with thawing and transfer in a subsequent cycle in high-responders

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitair Ziekenhuis Brussel
• Treatments: Chorionic Gonadotropin; Dimethyl Sulfoxide; Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Polyestradiol phosphate; Progesterone

Criteria

Inclusion Criteria:

• First or second IVF/ICSI cycle

• High response to ovarian stimulation (defined as presence of ≥18 follicles of ≥11 mm on the day of GnRH triggering)

• GnRH antagonist down-regulation

• Signed informed consent

• Patients can be included only once in the trial

• Planned replacement of 1 or 2 blastocysts

Exclusion Criteria:

• Other known reasons for impaired implantation (i.e. hydrosalpinx, fibroid distorting the endometrial cavity, Asherman's syndrome, thrombophilia or endometrial tuberculosis)

• Oocyte/embryos donation acceptors

• Embryos planned to undergo preimplantation genetic diagnosis/screening

• Body mass index ≥35 or ≤18

• Women who have previously enrolled in the trial

• Those unable to comprehend the investigational nature of the proposed study