Impact of the Inhibitors of Tyrosine Kinase on the Male Fertility

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

Evaluate the possible deleterious effects of tyrosine kinase inhibitors on sperm concentration, after 6 months of therapy, which corresponds to 2 cycles of spermatogenesis and on the sperm nuclear integrity. The main comparison criterion will be the mean difference in sperm concentration before and after the 6 month treatment.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Imatinib Mesylate

Criteria

Inclusion Criteria:

• Men from 18 to 60 years old

• Patients recently diagnosed CML or GIST

• Patients for whom a treatment by an inhibitor of tyrosine kinase in monotherapy is prescribed

• Patients having signed the informed consent

• Patients with social security

Exclusion Criteria:

• Patients already subjected to a treatment potentially sterilizing

• Patients under supervision or guardianship