Impact of Vitamin D Supplementation on Lactation Associated Bone Loss

• Status: Completed
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

Studies have shown that lactation is associated with a loss of bone density from four to seven percent at the spine and hip among women who lactate for six months. Decline in bone density with lactation occurs rapidly. Although bone density increases after weaning, there is controversy on whether or not it is completely restored. Epidemiological studies find no significant negative impact of lactation on bone mass or fractures, and in fact there is evidence that lactation has a positive effect on bone mass. We think that interventions that attenuate this physiologic loss of bone that is associated with lactation and accelerate restoration of bone mass after weaning may result in improved long term bone mass and diminished fracture risk.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Leigh Eck, MD
• Collaborator: Bio-Tech Pharmacal, Inc.
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Fully lactating mothers age 18 and up

• Within 1 month after delivery

• Plan to breast feed for at least 6 months

Exclusion Criteria:

• Known metabolic bone disease

• Chronic renal insufficiency

• Chronic corticosteroid use

• Eating disorder

• Estrogen containing hormonal contraception use

• Daily use of >400IU Vitamin D supplementation

• Delivery of Multiples

• Delivery of a singleton with a birth weight of <2500 grams

• Preterm delivery of baby

• History of kidney stones