Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients

• Status: Completed
• Trial end date: 0000-00-00
• Target enrollment: 53
• Participant gender: Both

Summary

In this study, investigators will evaluate the effect of vitamin C on endothelial function, exercise tolerance and quality of life in patients with a single ventricle who have been palliated to Fontan physiology. The hypothesis is that vitamin C will result in improved exercise tolerance and endothelial function in patients who have undergone the Fontan operation, compared to placebo.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Michigan
• Collaborator: Griese-Hutchinson Champions for Children's Hearts Investigator Award
• Treatments: Ascorbic Acid; Vitamins
• Last Updated: 2011-10-20

Criteria

Inclusion Criteria:

• 8-25 years of age

• Fontan-palliated patient

Exclusion Criteria:

• New York Heart Association (NYHA) classes III or IV

• Diabetes mellitus

• Family history of premature coronary artery disease

• Use of Sildenafil or other pulmonary artery vasodilators

• Prior cardiac arrest (outside the first 24-hours postoperatively)

• Life-threatening dysrhythmias

• Severe ventricular dysfunction

• Severe AV valve regurgitation

• Pregnancy

• Severe renal or hepatic impairment