Impact of Timing of Midazolam Administration on Incidence of Postoperative Nausea and Vomiting
Status:
Recruiting
Trial end date:
2022-04-15
Target enrollment:
Participant gender:
Summary
Postoperative nausea and vomiting (PONV), defined as nausea and/or vomiting occurring within
24 hours after surgery, affects between 20% and 30% of patients, As many as 70% to 80% of
patients at high risk may be affected. The etiology of PONV is thought to be multifactorial,
involving individual, anaesthetic and surgical risk factors. PONV results in increased
patient discomfort and dissatisfaction and in increased costs related to length of hospital
stay. Serious medical complications such as pulmonary aspiration, although uncommon, are also
associated with vomiting.
Patients with a higher risk of PONV often require a combination or multimodal approach of 2
or more interventions for effective risk reduction. Thus, researchers have explored
additional nontraditional antiemetics, such as midazolam, that would aid in the multimodal
prevention of PONV.