Impact of Tamsulosin on Post-Operative Urinary Retention Following Pelvic Reconstructive Surgery

• Status: Not yet recruiting
• Trial end date: 2023-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The objective of the study is to determine the effectiveness of postoperative Tamsulosin in reducing the duration of acute postoperative urinary retention (POUR) following pelvic reconstructive surgery through a double blind, randomized placebo-controlled trial.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
• Collaborator: Johns Hopkins University
• Treatments: Tamsulosin

Criteria

Inclusion Criteria:

• 18 years or older

• willing and able to provide informed consent

• postoperative urinary retention as defined by a failed RGVT prior to hospital discharge

• Ability to speak and read English

• Tolerate pill ingestion

Exclusion Criteria:

• allergy/intolerance to Tamsulosin or sulfa drugs

• preoperative history of urinary retention as defined by preoperative post void residual of >150mL

• current use of alpha antagonist medication for hypertension

• severe dementia

• end stage renal or liver disease

• history of severe heart failure or major cardiovascular event in the last 6 months