Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer

• Status: Completed
• Trial end date: 2018-04-05
• Target enrollment: 0
• Participant gender: All

Summary

Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate choice self-administration procedures between drug and a non-drug alternative reinforcer presented during maintenance on d-amphetamine, which has been previously shown to reduce cocaine use.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Joshua A. Lile, Ph.D.; University of Kentucky
• Treatments: Amphetamine; Cocaine; Dextroamphetamine

Criteria

Inclusion Criteria:

• Recent cocaine use, otherwise healthy

Exclusion Criteria:

• Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease