Maturity onset diabetes of the young (MODY) is a subtype of diabetes which is caused by
mutations in specific genes leading to diabetes. The most common cause of MODY is due to
mutations in the gene hepatocyte nuclear factor 1 alpha (HNF1A) and is consequently named
HNF1A-MODY (or MODY3). HNF1A-MODY is associated with urinary excretion of glucose at lower
blood glucose levels compared to other types of diabetes. Normally, glucose is reabsorbed by
sodium-glucose cotransporter 2 (SGLT2), but SGLT2 is downregulated due to the mutation in
HNF1A. Investigators aim to evaluate the impact of the decreased expression of SGLT2 on
glucosuria in patients with HNF1A-MODY compared to patients with type 2 diabetes (T2D) using
a single dose of an SGLT2 inhibitor during a glucose clamp experiment.