Impact of Rational Control of Fluid Balance in the Intensive Care Unit
Status:
Completed
Trial end date:
2019-04-01
Target enrollment:
Participant gender:
Summary
Patients admitted in the Intensive Care Unit (ICU) frequently display and excessive fluid
balance over a very short period of time. This positive fluid balance is the consequence of
different organ failures (pulmonary, cardio-vascular, kidney…) or aggressive fluid
resuscitation, which is mandatory in the early phase of ICU course. However recent data
strongly suggest that an excessive fluid balance could be detrimental per se (increase of ICU
morbidity or even mortality). There are controversies regarding the potential benefit of
controlling this fluid balance with diuretics which are commonly used worldwide in various
indications (acute and chronic heart failure, chronic kidney failure). In the ICU literature
data are lacking, regarding the possible advantages and drawbacks of diuretics in this
indication. The aim of our study is to test an algorithm with furosemide to reduce fluid
overload in severe ICU-patients.