Overview

Impact of Propofol Reduction in Anesthesia Induction

Status:
Completed
Trial end date:
2018-10-26
Target enrollment:
0
Participant gender:
All
Summary
Objective: Determine if, by reducing the dose of propofol and increasing the time elapsed between fentanyl and propofol administration, hemodynamic response is improved. Methods: Patients were randomized into time groups (2 and 1 minute) and each subdivided into dose groups (1, 1.5 and 2 mg kg-1) obtaining six time-dose groups. After receiving 2 μg kg-1 of fentanyl, propofol was administered after the predetermined time. Time to hypnosis (BIS<60) and hemodynamic parameters at pre-induction, pre-intubation and postintubation were registered.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Hospital Central de la Defensa Gómez Ulla
Treatments:
Anesthetics
Fentanyl
Propofol
Criteria
Inclusion Criteria:

- Adults who required general anesthesia

- General anesthesia with endotracheal intubation (no supraglottic devices)

- Signed informed consent

- Non-cardiac surgery

- Same anesthesiologist

Exclusion Criteria:

- Hemodynamic instability (systolic BP < 90 mmHg with clinical signs of low cardiac
output: impaired consciousness, diuresis <0.5 ml/kg/h, central venous saturation <60%
with normal arterial saturation or lactate >3 mmol/l)

- Increased risk of bronchoaspiration (absence of fasting, stomach retention, intestinal
obstruction, pregnancy, etc.)

- Suspected difficult airway

- Known allergy to anesthetic drugs