Impact of Propofol Reduction in Anesthesia Induction
Status:
Completed
Trial end date:
2018-10-26
Target enrollment:
Participant gender:
Summary
Objective: Determine if, by reducing the dose of propofol and increasing the time elapsed
between fentanyl and propofol administration, hemodynamic response is improved.
Methods: Patients were randomized into time groups (2 and 1 minute) and each subdivided into
dose groups (1, 1.5 and 2 mg kg-1) obtaining six time-dose groups. After receiving 2 μg kg-1
of fentanyl, propofol was administered after the predetermined time. Time to hypnosis
(BIS<60) and hemodynamic parameters at pre-induction, pre-intubation and postintubation were
registered.