Impact of Persistent Conductances on Motor Unit Firing in SCI
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This study is being done to measure the differences between the electrical activity of
muscles and /single muscle fibers in individuals with long-term spinal cord injury and
neurologically intact individuals without spinal cord injury. This study is also being done
to find out if muscle and /single muscle fiber electrical activity, voluntary strength,
reflex measurements, and/or spasms are changed after a single, oral dose of three commonly
prescribed drugs, Rilutek®, isradipine, and Namenda®. These medications are approved by the
FDA for treatment of disorders other than the control of spasms and strength. In this study,
they are being used in an experimental manner. Finally, this study is also being done to find
out whether or not a brief stretching exercise influences reflex measurements.
The main hypothesis of this study is that aberrant current activity in spinal motoneurons
contributes to spastic hyper-reflexia following chronic spinal cord injury.
Phase:
N/A
Details
Lead Sponsor:
Rehabilitation Institute of Chicago Shirley Ryan AbilityLab