Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin
Status:
Completed
Trial end date:
2015-10-01
Target enrollment:
Participant gender:
Summary
Periodontitis is an inflammatory/infectious disease of high prevalence in the population and
which has been linked to several chronic inflammatory systemic diseases. However, few studies
have evaluated the periodontal disease in the absence of other inflammatory conditions
stimulate inflammatory markers as C-reactive protein (CRP), Interleukin - 6 (IL-6) hepcidin
and hemoglobin. The aim of this study was to evaluate the influence of nonsurgical
periodontal therapy on the change of inflammatory markers and anemia in control subjects and
patients with chronic periodontitis after three months.This interventional study included 67
individuals of both sexes, aged 30-65 years, without other diseases, except chronic
periodontitis, with at least 20 teeth, selected from a total 125 individuals following the
eligibility criteria. Periodontal clinical parameters (probing depth, bleeding on probing,
clinical attachment level) and systemic, hematological as well as inflammatory markers CRP,
IL-6 and hepcidin were compared before and after nonsurgical periodontal therapy by serum and
plasma examination of control individuals and patients with chronic periodontitis.