Impact of Oral Versatile Antioxidants on Glaucoma Progression
Status:
Completed
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
Background: The significance of retinal ganglion cell protection in the glaucoma led the view
that, glaucomatous optical neuropathy can also be considered as a pathology of central
nervous system. It is known that α-tocopherol and Gingko Biloba have specific neuroprotective
and vasoregulatory activities, in addition to antioxidant effects. In this study, the
investigators compared early neuroprotective effects of α-tocopherol and GB with each other
as well as control and a strong antioxidant formulation in patients with glaucoma.
Methods: In this non-randomized control trial, 120 eyes of 60 patients with glaucoma were
enrolled into the study and divided into 4 groups, each consisting of 30 eyes. Unlike the
controls, patients in the 3 antioxidant groups received α-tocopherol, Gingko Biloba and a
strong antioxidant formula for 3 months. Central vision field and MD, PSD and OCT as well as
thickness of retinal nerve fiber layer, ganglion cell counts and c/d ratios were recorded.
The data were compared statistically.
Phase:
Phase 3
Details
Lead Sponsor:
Bagcilar Training and Research Hospital
Treatments:
alpha-Tocopherol Antioxidants Tocopherols Tocotrienols Vitamin E