Impact of Oral Antibiotic Treatment on C. Difficile

• Status: Completed
• Trial end date: 2017-06-27
• Target enrollment: 0
• Participant gender: All

Summary

The overall aim is to characterize and to compare the extent and quantity of C. difficile stool shedding, perianal colonization and environmental contamination in patients who received oral fidaxomicin, oral metronidazole, or oral vancomycin. This is a prospective, randomized, microbiologic and molecular, study of environmental contamination from patients with proven C. difficile associated diarrhea (CDAD).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Amebicides; Anti-Bacterial Agents; Antibiotics, Antitubercular; Fidaxomicin; Metronidazole; Vancomycin

Criteria

Inclusion Criteria:

• adult patients with microbiology-proven CDAD

• provides informed consent

• eligible to receive oral antibiotic therapy

Exclusion Criteria:

• prisoners

• pregnant women

• children <18 years

• patients who have contra-indications for perianal swabs, those who has medical conditions that would invalidate the results of the swabs

• patients requiring intravenous therapy for treatment of CDAD

• patients who do not consent and those who withdraw consent