Impact of Labor Analgesia on Serum Catecholamine Levels, Fetal Heart Rate and Uterine Tone in Pregnancies With Comorbidities

• Status: Completed
• Trial end date: 2020-10-16
• Target enrollment: 0
• Participant gender: Female

Summary

The combined spinal-epidural analgesia during the labor has been associated with more changes in fetal heart rate and uterine tonus than epidural analgesia, and the opinions in literature are not fully consolidated. The decrease of cathecolamines levels are implicated in this changes, but there is not studies in patients with comorbidities or with modern labor analgesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo General Hospital
• Treatments: Anesthetics; Bupivacaine; Dsuvia; Morphine; Sufentanil; Vasoconstrictor Agents

Criteria

Inclusion Criteria:

• previous diagnosis of intrauterine growth restriction

• maternal diseases that attend with chronic placental insufficiency (obesity, diabetes, arterial hypertension, kidney disease, thrombophilias, heart disease or lung disease for example)

Exclusion Criteria:

• patients ASA I or IV

• contraindications regional analgesia

• prior use of systemic opioids for the relief of labor pain

• amniotic, and maternal infection

• known fetal diseases