Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation

• Status: Recruiting
• Trial end date: 2023-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Missouri-Columbia
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• healthy adult men and women;

• 18-45 years of age;

• BMI 18-30 kg/m2;

• non-pregnant/non-breastfeeding;

• non-nicotine users;

Exclusion Criteria:

• taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic

Self-reported history of:

• hepatic, renal, pulmonary, cardiovascular, or neurological disease;

• stroke or neurovascular disease;

• bleeding/clotting disorders;

• sleep apnea or other sleep disorders;

• diabetes;

• smoking;

• history of alcoholism or substance abuse;

• hypertension;

• respiratory disease;

• active cancer;

• autoimmune disease.