Impact of Insecticide-treated Curtains on Antimalarial Drug Resistance
Status:
Completed
Trial end date:
2002-12-01
Target enrollment:
Participant gender:
Summary
Attempts to understand the relationship malaria transmission intensity and antimalarial drug
resistance had rested mainly on mathematical models. To date, except for two studies which
reported reductions in the prevalence of drug resistance in Tanzania and Zimbabwe, no other
field data addressed the impact of reducing malaria transmission by the use of vector control
measures on antimalarial drug resistance. Thus whether vector control decrease or increase
drug resistance remains a contentious issue. The aim of this study was to investigate the
impact of insecticide-treated curtains (ITCs) on clinical and parasitological outcomes in
children with uncomplicated malaria treated with chloroquine (CQ), on the prevalence of
genetic markers of resistance to CQ and sulphadoxine-pyrimethamine (SP) and on the ability of
children to clear drug resistant parasites. The therapeutic efficacy of CQ was studied in 9
villages which used ITCs for 6-8 years and 9 villages with no history of ITC use. A
cross-sectional survey was also conducted to estimate the prevalence of genetic markers of
resistance to CQ and SP in asymptomatic children.
Phase:
N/A
Details
Lead Sponsor:
Gates Malaria Partnership London School of Hygiene and Tropical Medicine