Impact of Immediate Versus South African Recommendations Guided ART Initiation on HIV Incidence
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
This trial is evaluating a public health intervention strategy trial which aims to reduce the
incidence of HIV at a population-level.
The proposed strategy is a two steps process:
- Extensive HIV counselling and testing, and comprehensive prevention programme among a
target population
- Immediate ART initiation after HIV diagnosis, irrespective of CD4 count criteria.
The underlaying trial hypothesis is that HIV testing followed by immediate ART initiation of
all HIV-infected individuals will prevent onward transmission and reduce HIV incidence in the
population. This is a cluster randomised controlled trial with a total of 22 communities used
as the units for randomisation. Enrolment of a population of 22 000 individuals among which 4
400 are expected to be HIV-Infected.
Phase:
N/A
Details
Lead Sponsor:
ANRS, Emerging Infectious Diseases French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)
Collaborators:
Africa Centre For Health and Population Studies Africa Centre For Health and Population Studies, South Africa University of KwaZulu