Impact of High-dose Pretreatment of Rosuvastatin in Patients With Acute Coronary Syndrome Following Off-pump Coronary Artery Bypass: Results From the HIROP-ACS (HIgh-dose Pretreatment of Rosuvastatin During Off-Pump Coronary Bypass in Acute Coronary

• Status: Completed
• Trial end date: 2013-03-01

Summary

Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions.

-Objective: to determine whether preoperative rosuvastatin loading is independently associated with reduced myocardial ischemia and clinical outcomes in patients with stable angina undergoing isolated off-pump coronary bypass (OPCAB) in patients with acute coronary syndrome.

Study design

• Prospective, double-blinded, single-center study of each 117 subjects enrolled

• Subjects with acute coronary syndrome who meet all inclusion and exclusion criteria will be enrolled preoperatively.

• Eligible subjects will be randomized 1:1 to A) High-dose rosuvastatin (n=117) vs. B) Placebo (n=117).

• The amount of preoperative administration of high-dose rosuvastatin will be 60mg of a total

• All subjects will undergo OPCAB procedure. - The primary and secondary endpoints will be compared at 30 days and 2 years postoperatively between two groups

• Phase: Phase 4

Details

• Lead Sponsor: Yonsei University
• Treatments: Rosuvastatin Calcium