Impact of GABA-Enhancing Agents on Cortical GABA Concentrations Across the Menstrual Cycle in Women
Status:
Completed
Trial end date:
2009-02-01
Target enrollment:
Participant gender:
Summary
The goal of this series of challenge studies is to examine the impact of menstrual cycle
phase on cortical GABA response to administration of agents with either direct
(benzodiazepines) or indirect (progesterone, fluoxetine) GABA modulating properties. While
the impact of these agents on cortical GABA levels in women with premenstrual dysphoric
disorder (PMDD) is of interest, this study is designed primarily for those women without a
psychiatric illness.