Impact of Formulation on Ciprofloxacin Oral Absorption
Status:
Completed
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
The purpose of this research is to see if certain tablet formulation factors affect oral drug
absorption. Medications taken by mouth, such as tablets, need to be absorbed into the body in
order to do any good. Tablets contain a drug, but also contain non-drug ingredients that are
called excipients or fillers. Excipients in the tablet, and the way in which the tablet is
manufactured, both can impact how much drug is absorbed into the body. That is, tablet
formulation factors can cause a tablet to be effective or not effective.
Tablets in this research contain the drug ciprofloxacin hydrochloride. Ciprofloxacin is an
antibiotic to treat infections, such as lung infections. This drug is being used since it has
low water solubility and is probably sensitive to tablet formulation factors.
Phase:
Phase 1
Details
Lead Sponsor:
University of Maryland University of Maryland, Baltimore