Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes

• Status: Not yet recruiting
• Trial end date: 2022-05-31
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this application is to test whether menthol and fruit flavors impact e-cigarette use through dissociable mechanisms and exert their effects differentially across nicotine doses.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yale University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Menthol; Nicotine

Criteria

Inclusion Criteria:

• Past month daily cigarette, nicotine-containing e-cigarette, and/or cigar/little cigar/cigarillo use.

• Urine cotinine levels consistent with regular nicotine use

• For women, using acceptable birth control methods

• Able to read and write English

Exclusion Criteria:

• Current or history of major medical illness psychiatric diagnosis or substance use or psychotropic medication use that the physician investigator deems a contraindication for study participation

• Current psychiatric diagnosis of bipolar affective disorder, schizophrenia, homicidal or suicidal ideation

• Any allergy to propylene glycol, vegetable glycerin, menthol, mint, green apple or watermelon flavorants

• For women, pregnant as determined by pregnancy screening, or breast feeding

• Seeking (or undergoing) treatment for nicotine dependence or smoking

• Inability/unwillingness to fulfill scheduled visits and procedures including directed self-administration of all e-liquid flavors