Impact of Fentanyl Analgesia on the Accuracy of HVPG Measurements in Patients With Portal Hypertension
Status:
Not yet recruiting
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
Portal hypertension is a common complication of chronic liver disease and is associated with
most clinical consequences of cirrhosis. The most reliable method for assessing portal
hypertension is the measurement of the hepatic venous pressure gradient (HVPG). The HVPG is
the gold-standard methods for assessing clinically significant portal hypertension and
becoming increasingly used clinically. It is useful in the differential diagnosis of portal
hypertension and provides a prognostic index in cirrhotic patients. Many patients are painful
and reluctant to undergo serial HVPG measurements. But interventionists are reluctant to use
analgesics because they always pay more attention to the accuracy of HVPG
measurements.Although Adam F. et al concluded that low-dose midazolam sedation is an option
for patients undergoing serial hepatic venous pressure measurements (Hepatology 1999), the
effects of using opioid analgesics alone on hepatic venous pressure measurements have not yet
been defined. The objective of this study was to evaluate the effects of fentanyl on the
HVPG.
Phase:
N/A
Details
Lead Sponsor:
Hepatopancreatobiliary Surgery Institute of Gansu Province
Collaborators:
LanZhou University Lishui hospital of Zhejiang University The First Affiliated Hospital with Nanjing Medical University The First Affiliated Hospital, Zhejiang University School of Medicine