Overview Impact of Estradiol Addback Status: Completed Trial end date: 2018-12-30 Target enrollment: Participant gender: Summary Repletion of testosterone (T) in older men drives Growth Hormone secretion after its aromatization to estradiol (E2) by potentiating endogenous GH drive. Phase: Phase 1 Details Lead Sponsor: Mayo ClinicTreatments: AnastrozoleEstradiolEstrogensTestosterone