Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients
Status:
Completed
Trial end date:
2017-02-20
Target enrollment:
Participant gender:
Summary
Post-Operative Cognition Dysfunction (POCD) is a common complication after surgery, POCD can
lead to a reduced ability and seriously affect the quality of life of patients, increase
personal and social burden, POCD may also increase mortality.POCD can occur at any age, but
the long-term, affect the daily lives of POCD in elderly patients over 60 years of age are
more prone. Age is a risk factor for advanced or long-term POCD. POCD determined by
preoperative cognitive function and psychological scales postoperative assessment, the main
recommendation of the agreed test methods include, Rey auditory verbal test, the connection
test, digit span test. In this study, preoperative mini-mental state examination (MMSE)
screening, comprehensive neurological function during hospitalization for memory, attention,
executive function and exercise capacity test, and telephone follow-up after discharge Scale
Revised (TICS-M) test.
Few study showed that dexmedetomidine may improve cognitive function in young patients others
show that dexmedetomidine did not reduce POCD incidence after 24 hours of surgery. These
results conflict and it is necessary to carry out large-scale, multi-center, randomized,
controlled clinical study to determine whether dexmedetomidine reduce the POCD incidence or
not for elderly patients.
Phase:
Phase 4
Details
Lead Sponsor:
The First Affiliated Hospital of Anhui Medical University