Overview

Impact of Budesonide on Incidence of ≥ Gr2 Diarrhea in Multiple Myeloma (MM) Patients Undergoing Autologous Stem Cell Transplant

Status:
Not yet recruiting
Trial end date:
2027-08-15
Target enrollment:
0
Participant gender:
All
Summary
A randomized placebo controlled, phase 2 study of budesonide in subjects with multiple myeloma undergoing autologous stem cell transplant. The study includes a run-in period with 20 patients.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Utah
Treatments:
Budesonide
Criteria
Inclusion Criteria:

- Subject aged ≥ 18 years.

- Histologically confirmed multiple mylemona undergoing ASCT who are determined to be
fit by the investigator to undergo ASCT with melphalan 200 mg/m2 as conditioning.

- Able to provide informed consent and willing to sign an approved consent form that
conforms to federal and institutional guidelines.

- Adequate organ function as defined as:

--Hepatic:

- Total Bilirubin ≤ 2 x institutional upper limit of normal (ULN).

- AST(SGOT)/ALT(SGPT) ≤ 5 × institutional ULN

- For female subjects: Negative pregnancy test or evidence of post-menopausal status.
The post-menopausal status will be defined as having been amenorrheic for 12 months
without an alternative medical cause. The following age-specific requirements apply:

- Women < 50 years of age:

- Amenorrheic for ≥ 12 months following cessation of exogenous hormonal
treatments; and

- Luteinizing hormone and follicle-stimulating hormone levels in the
post-menopausal range for the institution; or

- Underwent surgical sterilization (bilateral oophorectomy or hysterectomy).

- Women ≥ 50 years of age:

- Amenorrheic for 12 months or more following cessation of all exogenous
hormonal treatments; or

- Had radiation-induced menopause with last menses >1 year ago; or

- Had chemotherapy-induced menopause with last menses >1 year ago; or

- Underwent surgical sterilization (bilateral oophorectomy, bilateral
salpingectomy, or hysterectomy).

Inclusion Criteria required for Patients Enrolling in Safety Run-In Cohort only:

-Patient must have at least 2.5 x 106 CD34 cells in reserve for use if engraftment is
delayed

Exclusion Criteria:

- Prior use of budesonide for any medical condition

- Receiving other investigational agents, unless deemed acceptable after consultation
with the PI

- Subjects with moderate or severe pre-existing hepatic impairment as classified
according to the Child-Pugh system.

- Prior history or current diagnosis of inflammatory bowel disease, microscopic colitis
or chronic diarrhea at baseline.

- Prior history of receiving an allogenic stem cell transplant

- Current evidence or diagnosis of microscopic colitis or chronic diarrhea at time of
screening

- History of other malignancies with the exception of malignancies for which all
treatment was completed ≥ 2 years before study enrollment and are considered to be
adequately treated with no evidence of disease or symptoms and/or will not require
therapy during the study duration.

- Known active brain metastases or cranial epidural disease.

--Note: Brain metastases or cranial epidural disease adequately treated with
radiotherapy and/or surgery and stable for at least 4 weeks before the first dose of
study treatment will be allowed on trial. Subjects must be neurologically asymptomatic
and without corticosteroid treatment at the time of the first dose of study treatment.

- Medical, psychiatric, cognitive, or other conditions that may compromise the subject's
ability to understand the subject information, give informed consent, comply with the
study protocol or complete the study.

- Known prior severe hypersensitivity to melphalan or budesonide or any component in
their formulations or compounds of similar composition (NCI CTCAE v5.0 Grade ≥ 3).

- Subjects taking prohibited medications as described in Section 6.6.1. A washout period
of prohibited medications for a period of at least five half-lives or 14 days
(whichever is shorter) should occur before the start of treatment.