Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium

• Status: Completed
• Trial end date: 2017-11-26
• Target enrollment: 0
• Participant gender: All

Summary

Surgery is one of the major treatment methods for patients with malignant tumor. And, alone with ageing process, more and more elderly patients undergo surgery for malignant tumor. Evidence emerges that choice of anesthetics, i.e., either inhalational or intravenous anesthetics, may influence the outcome of elderly patients undergoing cancer surgery. Delirium is a commonly occurred early postoperative cognitive complication in the elderly, and its occurrence is associated with the worsening outcomes. Choice anesthetics may influence the occurrence of postoperative delirium. However, evidence in this aspect is conflicting.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University First Hospital
• Collaborators: Affiliated Hospital of Qinghai University; Beijing Cancer Hospital; Beijing Shijitan Hospital, Capital Medical University; Cancer Hospital of Guangxi Medical University; China-Japan Friendship Hospital; Guizhou Provincial People's Hospital; Hebei Medical University Fourth Hospital; Peking University; Peking University Hospital of Stomatology; Peking University Third Hospital; Shaanxi Provincial People's Hospital; Shanxi Province Cancer Hospital; Shenzhen Second People's Hospital; Tang-Du Hospital; The First Affiliated Hospital of Zhengzhou University; The People's Hospital of Ningxia; The Third Xiangya Hospital of Central South University; Tianjin Nankai Hospital; Zhongda Hospital
• Treatments: Anesthetics; Benzocaine; Fentanyl; Nitrous Oxide; Propofol; Remifentanil; Sevoflurane; Sufentanil

Criteria

Inclusion criteria

Participants will be included if they meet all the following criteria:

1. Age ≥ 65 years and < 90 years;

2. Primary malignant tumor;

3. Do not receive radiation therapy or chemotherapy before surgery;

4. Scheduled to undergo surgery for the treatment of tumors, with an expected duration of 2 hours or more, under general anesthesia;

5. Agree to participate, and give signed written informed consent.

Exclusion criteria

Patients will be excluded if they meet any of the following criteria:

1. Preoperative history of schizophrenia, epilepsy, parkinsonism or myasthenia gravis;

2. Inability to communicate in the preoperative period (coma, profound dementia, language barrier, or end-stage disease);

3. Critical illness (preoperative American Society of Anesthesiologists physical status classification ≥ IV), severe hepatic dysfunction (Child-Pugh class C), or severe renal dysfunction (undergoing dialysis before surgery);

4. Neurosurgery;

5. Other reasons that are considered unsuitable for participation by the responsible surgeons or investigators (reasons must be recorded in the case report form).