Impact of Acetazolamide in Reducing Referred Postoperative Pain
Status:
Recruiting
Trial end date:
2021-08-01
Target enrollment:
Participant gender:
Summary
Robotic assisted laparoscopic prostatectomy (RALP) is the standard treatment for prostate
cancer, due to the benefits of decreased blood loss and length of stay.The procedure involves
removing a man's prostate using a minimally invasive robotic approach under the guidance of a
surgeon. In order to gain sufficient access, carbon dioxide (CO2) is used to fill the
surgical space in a process termed insufflation. Carbon dioxide is a mainstay in laparoscopic
procedures because it is cost-effective, noncombustible and readily excreted via the
respiratory system in healthy patients.
Insufflation with CO2, however, has been linked to post-operative referred pain secondary to
peritoneal acidosis.This acidosis is suspected to be due to the formation of carbonic acid
from the CO2 insufflation.Peritoneal acidosis, and its associated post-operative referred
pain, may not be adequately treated with the current standard pain control regimen.