Overview

Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis

Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
0
Participant gender:
All
Summary
Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Centre Hospitalier Universitaire de NÄ«mes
Treatments:
Amikacin
Gentamicins
Criteria
Inclusion Criteria:

- ICU patient with severe sepsis

- Treated with aminoglycosides

Exclusion Criteria:

- Renal replacement therapy

- Allergy to aminoglycosides

- Confirmed and/or suspected to have myasthenia

- ICU-acquired neuromuscular disorder

- Under guardianship

- Prisoners

- The patient has already participated in the present protocol