Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R
Status:
Withdrawn
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
Endpoint implementation of reactions initiated by ischemia is the mitochondrial transition
pore permeability. Mitochondria pores opening results in a release of factors triggering
apoptosis primarily the cytochrome ะก Inhibition of the pores opening protects ischemic damage
of the cells. The key enzyme regulating the mitochondrial permeability transition pore is
GSK-3b: the phosphorylation of the enzyme inactivates the enzyme and prevents pore opening.
Aim of studi is to determine content of the phosphorylatcd GS K-3b in neurons of rat brain in
the model of total tschemia/reperfusion.