Immunotherapy With NK Cell, Rituximab and Rhu-GMCSF in Non-Myeloablative Allogeneic Stem Cell Transplantation
Status:
Completed
Trial end date:
2019-07-22
Target enrollment:
Participant gender:
Summary
The goal of this clinical research study is to find out if giving a boost of natural killer
(NK) cells from a donor combined with Rituxan (rituximab), can help to control disease in
patients who have already received an allogeneic stem cell transplant. The safety of this
treatment will also be studied. Participants have recurrent chronic lymphocytic leukemia
(CLL) or lymphoma after non-myeloablative stem cell transplantation.
Primary Objectives:
1.0 To determine the safety of Natural Killer (NK) cells and Rituximab +
rhu-Granulocyte-macrophage colony-stimulating factor (GMCSF) in patients with persistent or
recurrent B-cell lymphoid malignancies after non-myeloablative stem cell transplantation.
2.0 To determine factors associated with response.