Immune Response To Intranasal Influenza Vaccination
Status:
Active, not recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
This research during the last decade has focused on the kinetics of the systemic and local
immune response to parenteral influenza vaccine in humans. The investigators have shown that
normally high numbers of influenza specific antibody secreting cells (ASC) are present in the
nasal mucosa of healthy adults but upon parenteral vaccination the numbers remain stable.
However, a rapid transient increase in specific ASC is observed in the tonsils and peripheral
blood after parenteral vaccination. In the tonsils, this is associated with a significant
decrease in both naïve/effector (CD45RA+) and memory (CD45RO+) CD4+ cells upon vaccination.
In this study the investigators will extend our work to investigate the characteristics of
influenza-specific T- and B-cells induced locally and systemically after intranasal
vaccination in man.