Immune Reconstitution in naïve HIV Patients With CD4 <100 Cells/mL When Treated With Lopinavir or Efavirenz.

• Status: Terminated
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Pilot, randomized, parallel, open-label, controlled, clinical study evaluating virological response in plasma and extra-plasmatic compartments, together with the degree and kinetics of immune reconstitution in treatment-naïve patients with CD4 count below 100 cells/mL, when treated with tenofovir and abacavir together with lopinavir or efavirenz.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Clinic of Barcelona
• Treatments: Abacavir; Dideoxynucleosides; Efavirenz; Lopinavir; Ritonavir; Tenofovir

Criteria

Inclusion Criteria:

• HIV-infection

• Antiretroviral-naive

• CD4 cell count below 100 cells/mm3

Exclusion Criteria:

• Pregnancy

• Current opportunistic infection requiring parenteral therapy

• Current malignancies requiring parenteral chemotherapy

• Any contraindication to the study drugs