The main objective of this study is to test if naltrexone, when taken in low doses, has an
anti-inflammatory effect that may be associated with positive clinical outcomes in people
with chronic fatigue syndrome (CFS). In part, the present study, is a continuation of prior
work in which we showed that chronic fatigue symptoms are associated with immune activity,
and that low-dose naltrexone might exert anti-inflammatory effects in fibromyalgia, which is
thought to share some pathophysiological and clinical characteristics with CFS.