Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis
Status:
Unknown status
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
The optimal time to initiate antiretroviral therapy (ART) in HIV-associated tuberculous
meningitis (TBM) unknown. There are concerns that immediate ART may worsen rather than
improve outcome, because drug interactiond and toxicities or development of an intracerebral
immune reconstitution inflammatory syndrome (IRIS). Conversely, delaying ART may result in
increased HIV-related deaths. To answer this question, we are conducting a randomised,
double-blind placebo-controlled trial comparing immediate and deferred ART in HIV-infected
patients presenting with TBM, to assess effect on survival.