Imipramine and Pregabalin Combination in Painful Polyneuropathy
Status:
Unknown status
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
Polyneuropathy of different etiologies is often associated with pain and the standard
treatment for this type of pain is gabapentinoids or antidepressants. The hypothesis of this
study is that the combination of the gabapentinoid pregabalin and the antidepressant
imipramine will provide better pain relief than the single compounds alone.
This is a randomized, placebo-controlled, double-blind, 4-way, cross-over trial of pregabalin
300 mg/day, imipramine 75 mg/day and their combination versus placebo. The study will include
60 patients and the treatment outcome will be pain intensity as measured by numeric rating
scales.