Type 1 diabetes results from the autoimmune destruction of the insulin-producing beta cells
of the islets of Langerhans of the pancreas. Initially, diabetes is usually clinically silent
with immune cells invading the pancreatic islets, a process termed insulitis, which
eventually leads to loss of beta cells in the islets. If enough beta cells are destroyed, the
body can not make enough insulin to maintain blood sugars in the normal range and clinical
diabetes develops. The purpose of this study is to assess the ability of magnetic resonance
imaging with ferumoxytol to detect changes in the pancreas associated with the insulitis of
type 1 diabetes.
Details
Lead Sponsor:
Jason Gaglia
Collaborators:
Harvard Medical School Harvard Medical School (HMS and HSDM) National Institute of Allergy and Infectious Diseases (NIAID)