Overview

Imaging of Peri-operative (periOP) Lung Injury

Status:
Terminated
Trial end date:
2020-02-05
Target enrollment:
0
Participant gender:
All
Summary
The aim of study is to determine if 99mTc Annexin V-128 (AxV- 128/Tc) single photon emission computed tomography (SPECT)-computed tomography (CT) can detect perioperative lung injury. The investigators will study patients undergoing major surgery, specifically Whipple procedures (pancreatico-duodenectomies) and compare AxV-128/Tc SPECT-CT scans before and after surgery in Chronic Obstructive Pulmonary Disease (COPD) and non-COPD patients.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Columbia University
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Criteria
Inclusion Criteria:

- Patients with moderate COPD (Global Initiative for Chronic Obstructive Lung Disease
(GOLD) stage II: forced expiratory volume 1 (FEV1)/forced vital capacity (FVC) <0.70
and FEV1 50-79% normal) undergoing Whipple procedures or other major surgeries

- Patients with normal lung function undergoing Whipple procedures or other major
abdominal surgeries

Exclusion Criteria:

- Age < 18 years