This study uses [11C]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge
to image the interaction between nociceptive opioid peptide (NOP) receptors and
cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD)
and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP
interactions predict relapse in subjects with CUD.