Imaging 5HT7 Antagonist Effects in Bipolar Disorder
Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
The main aim of this research is to examine the potential of 5HT7 antagonists for the
treatment of cognitive impairment in bipolar disorder by determining the effect of the 5HT7
antagonist JNJ-18038683 on cognitive and emotional processing related brain activity in
cognitively impaired people with bipolar disorder and healthy participants using functional
MRI (fMRI). This study is designed to contribute to the rational validation of 5HT7
antagonists as a treatment for cognitive impairment in bipolar disorder and to support the
development of clinical trials and further drug development in this area. The study will also
examine the effect of 5HT7 antagonism on brain function in healthy participants as this has
never been investigated before, and to use as a comparator to determine whether 5HT7
antagonism effects disease specific impairments in task related brain activity and cerebral
blood flow.