Image Guided Surgery in Sinonasal Inverted Papilloma
Status:
Active, not recruiting
Trial end date:
2022-01-01
Target enrollment:
Participant gender:
Summary
In sinonasal inverted papilloma (SNIP) it is very challenging to discriminate between tumor
and surrounding tissue. Local recurrence is a frequent phenomenon as it occurs in 16.5% of
the cases. There is need for an instrument that is able to guide the surgeon in removing all
tumor tissue, whereas resection of healthy tissue is minimalized.
Molecular fluorescence guided surgery enables the visualization of targeted tumor-specific
biomarkers by using fluorescence, thereby enhancing the contrast between normal mucosa and
tumor tissue. The objective of this feasibility study is to determine if the intravenously
administered conjugate bevacizumab-IRDye800CW accumulates more in SNIP than in normal
sinonasal epithelium.