Ifosfamide With or Without O(6)-Benzylguanine in Treating Patients With Unresectable, Metastatic Solid Tumors
Status:
Terminated
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This randomized phase I trial is studying the side effects and best dose of
O(6)-benzylguanine when given together with ifosfamide and to see how well it works compared
to ifosfamide alone in treating patients with unresectable metastatic solid tumors. Drugs
used in chemotherapy, such as ifosfamide and O(6)-benzylguanine, work in different ways to
stop tumor cells from dividing so they stop growing or die. Combining ifosfamide with
O(6)-benzylguanine may kill more tumor cells