Identifying Brain and Genetic Markers of Sertraline Treatment Response in People With Social Anxiety Disorder

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will attempt to identify gene and brain activity markers that predict whether people with social anxiety disorder will respond to selective serotonin reuptake inhibitor medications.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Michigan
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Sertraline

Criteria

Inclusion Criteria:

For social anxiety disorder group:

• Current diagnosis of social anxiety disorder, generalized subtype

• Physically healthy, as confirmed by comprehensive medical history, physical exam, and laboratory testing

For healthy control group:

• Never been diagnosed with either Axis I or Axis II mental disorders

• Physically healthy, as confirmed by comprehensive medical history, physical exam, and laboratory testing

Exclusion Criteria:

• Clinically significant medical or neurologic condition

• Diagnosis of primary comorbid anxiety disorder, defined by which disorder is the more debilitating and clinically salient

• History of bipolar disorder or schizophrenia

• Presence of an organic mental syndrome, mental retardation, or pervasive developmental disorder

• Current major depressive disorder or major depression within the past 6 months

• Hamilton Rating Scale for Depression score greater than 18

• Alcohol or drug abuse or dependence within the past year

• Current suicidal ideation

• Diagnosis of an Axis II personality disorder, except for avoidant personality disorder

• Treatments with psychotropic or psychoactive medications within the 2 weeks before screening (or 8 weeks for fluoxetine and 4 weeks for monoamine oxidase inhibitors)

• Positive urine drug screen results

• Pregnancy

Additional exclusion criteria for the functional MRI studies:

• Left-handedness, as determined by standard questionnaire

• Presence of ferrous-containing metals within the body, such as aneurysm clips, shrapnel, or retained particles

• Claustrophobia