Identification of Genetic Markers and Predictors of Antidepressant-induced Suicidality in Youth Depression

• Status: Unknown status
• Trial end date: 2020-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to identification of genetic markers and predictors of antidepressant-induced suicidality in youth depression. Participants who take the standardized pharmacotherapy (bupropion or lamotrigine) for depression will be observed for 8 weeks. They will do several scales and genetic tests at visit 1 (week 0), visit 3 (week 4) and visit 4 (week 8)

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Asan Medical Center
• Treatments: Anticonvulsants; Antidepressive Agents; Bupropion; Lamotrigine

Criteria

Inclusion Criteria:

1. Aged between 11 and 18 years

2. Met the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL) diagnostic criteria for depressive episode or dysthymia

3. Intelligence quotient higher than 70 on the Korean Educational Developmental Institute's Wechsler Intelligence Scale for Children

Exclusion Criteria:

1. presence of intellectual disability

2. presence of hereditary disorder

3. past and/or current history of acquired brain injury, like cerebral palsy

4. presence of seizure, other neurological disorder or sensory impairments

5. past and/or current history of pervasive developmental disorder

6. past and/or current history of schizophrenia, bipolar disorder or psychosis

7. presence of severe learning disorder