Identification of Drug-drug Interaction Between Tacrolimus and Mycophenolate Mofetil in Healthy Adults
Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
Coadministration of tacrolimus and mycophenolate mofetil is frequent in kidney
transplantation. Due to narrow therapeutic range of tacrolimus and mycophenolate mofetil,
therapeutic drug monitoring with dose adjustment is required. Investigating pharmacokinetic
interplay between two drugs enables fine dose adjustment, while mechanism of drug interaction
between two drugs is still not well understood. Therefore, an open-label, three period,
single dose trial is planned to investigate the drug interaction between tacrolimus and
mycophenolate mofetil.