Ideal Dose of Phenylephrine to Treat Low Blood Pressure During Cesarean Section

• Status: Completed
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine the minimum effective bolus dose of phenylephrine to prevent post-spinal hypotension in Cesarean section in 95 % of our patients. An adequate response will be defined as the absence of hypotension or nausea/vomiting during the period from induction of spinal anesthesia to uterine incision prior to fetal delivery.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
• Treatments: Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• Elective CS under spinal anesthesia

• Normal singleton pregnancy beyond 36 weeks gestation

• ASA physical status I/II

• Weight 50-100 kg, height 150-180 cm

• Age over 18 years

Exclusion Criteria:

• Patient refusal

• Allergy or hypersensitivity to phenylephrine

• Preexisting or pregnancy-induced hypertension

• Cardiovascular or cerebrovascular disease

• Fetal abnormalities

• History of diabetes, excluding gestational diabetes