Ibuprofen vs. Continuous Indomethacin in the Treatment of PDA

• Status: Completed
• Trial end date: 2006-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether closure of the PDA in premature neonates using IV ibuprofen vs continuous IV indomethacin has different side effects, eg. effects on renal function, on blood flow velocity in the superior mesenteric artery, the anterior cerebral artery, and the renal artery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shaare Zedek Medical Center
• Treatments: Ibuprofen; Indomethacin

Criteria

Inclusion Criteria:

• < 1500 gm birth weight with PDA confirmed by echocardiography

Exclusion Criteria:

• Additional congenital heart lesions

• Significant congenital malformations

• Documented infection

• Thrombocytopenia (<60,000)

• IVH grade 4