Ibuprofen Supplementation After Resistance Training and Its Effects on Bone in Older Women
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
Inflammation increases with aging and is implicated in the reduction of bone mass, muscle
mass, and strength. Resistance training is safe and effective for increasing muscle mass and
strength in older adults,however resistance training by itself cannot suppress inflammation.
Ibuprofen is a non-steroidal anti-inflammatory drug that may provide benefits to muscle mass
and strength when given after resistance training sessions in older adults; however, more
evidence is required to confirm effects across the lifespan. The objectives are to determine
the effect of 9 months of exercise training and ibuprofen supplementation, compared to
placebo, in older women (≥65years)on the following dependent variables:
- bone density, geometry, and architecture
- muscle mass and strength
- balance