IVF Versus Gonadotropin Therapy in Women With CC Resistant PCOS

• Status: Withdrawn
• Trial end date: 2017-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to compare the efficacy of in vitro fertilization (IVF) versus gonadotropin therapy in infertile women having clomiphene citrate (CC) resistant polycystic ovarian syndrome (PCOS).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mohamed Sayed Abdelhafez
• Treatments: Clomiphene; Enclomiphene; Menotropins; Zuclomiphene

Criteria

Inclusion Criteria:

• Infertile women with PCOS as defined by the Rotterdam criteria.

• CC resistance (defined as failure of ovulation after receiving 150 mg/day of CC for 5 consecutive days per cycle, for at least 3 consecutive cycles).

Exclusion Criteria:

• Age < 20 or > 35 years.

• Presence of any infertility factor other than anovulatory PCOS.

• Previous history of ovarian surgery or surgical removal of one ovary.

• Previous exposure to cytotoxic drugs or pelvic irradiation.

• Oral hypoglycemic or hormonal therapy either currently or in the preceding 3 months.

• Metabolic or hormonal abnormalities.